靈芝裡蘊藏的三萜類之豐富，科學家挖掘了近四十年還挖掘不完，目前已經知道的就快二百種，作用巧妙也不盡相同。

日本富山大學的學者則在紫芝（Ganoderma sinense）子實體分離出多種三萜類和固醇類，其中3種新的羊毛固烷型三萜類（ganoderic acid GS-2、20-hydroxylucidenic acid N和20(21)-dehydrolucidenic acid N）和靈芝醇Ｆ（ganoderiol F），都具有抑制HIV-1病毒的作用，其半數抑制濃度（IC50）為20～40 microM。

（以上文章原刊登於49期《健康靈芝》雜誌）4495

Chem Pharm Bull (Tokyo). 2009 Oct;57(10):1076-80.
Anti-human immunodeficiency virus-1 protease activity of new lanostane-type triterpenoids from Ganoderma sinense.
Sato N, Zhang Q, Ma CM, Hattori M.
Source
Institute of Natural Medicine, University of Toyama, Sugitani, Toyama 930-0194, Japan.

Abstract
Five new highly oxygenated lanostane-type triterpenoids [ganoderic acid GS-1 (1), ganoderic acid GS-2 (2), ganoderic acid GS-3 (3), 20(21)-dehydrolucidenic acid N (4) and 20-hydroxylucidenic acid A (5)] were isolated from the fruiting body of Ganoderma sinense, together with known compounds including 6 triterpenoids and 3 sterols. The structures of the new triterpenoids determined by spectroscopic means including 2D NMR were 7beta-hydroxy-3,11,15-trioxo-lanosta-8,24(E)-dien-26-oic acid (1), 7beta,15alpha-dihydroxy-3,11-dioxo-lanosta-8,24(E)-dien-26-oic acid (2), 12beta-acetoxy-3beta,7beta-dihydroxy-11,15-dioxo-lanosta-8,24(E)-dien-26-oic acid (3), 3beta,7beta-dihydroxy-11,15-dioxo-25,26,27-trinorlanosta-8,20-dien-24-oic acid (4), and 7beta,20xi-dihydroxy-3,11,15-trioxo-25,26,27-trinorlanost-8-en-24-oic acid (5), respectively. Among these, ganoderic acid GS-2, 20-hydroxylucidenic acid N, 20(21)-dehydrolucidenic acid N and ganoderiol F inhibited human immunodeficiency virus-1 protease with IC(50) values of 20-40 microM.

［資料來源］Sato N, et al.: Anti-human immunodeficiency virus-1 protease activity of new lanostane-type triterpenoids from Ganoderma sinense. Chem Pharm Bull (Tokyo). 2009 Oct;57(10):1076-80.http://goo.gl/f9GqeChem Pharm Bull (Tokyo). 2009 Oct;57(10):1076-80.