靈芝裡蘊藏的三萜類之豐富，科學家挖掘了近四十年還挖掘不完，目前已經知道的就快二百種，作用巧妙也不盡相同。

瑞士Basel大學的學者則證實，靈芝乙酸乙酯萃取物有很好的抗虐疾作用──在4.9µ g/ml濃度時可達到79%的抑制效果。進一步將此粗萃物做更新一步的分離純化，確認其中三種新發現的羊毛固烷型三萜類，是靈芝抗虐疾活性的主要來源，它們在6～20 µ M濃度下可使半數以上的虐疾原蟲嗚乎衰哉。

（以上文章原刊登於49期《健康靈芝》雜誌）4495

［資料來源］Adams M, et al.: Antiplasmodial lanostanes from the Ganoderma lucidum mushroom. J Nat Prod. 2010 May 28;73(5):897-900.J Nat Prod. 2010 May 28;73(5):897-900.

Antiplasmodial lanostanes from the Ganoderma lucidum mushroom.
Adams M, Christen M, Plitzko I, Zimmermann S, Brun R, Kaiser M, Hamburger M.
Source
Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.

Abstract
In a screen of 880 extracts from plants and fungi for antiplasmodial, antitrypanosomal, and leishmanicidal activity, an ethyl acetate extract of the mushroom Ganoderma lucidum showed antiplasmodial activity with 79% inhibition at 4.9 microg/mL. HPLC-based activity profiling and subsequent isolation of the antiplasmodial compounds yielded seven lanostanes (1-7), of which three (2, 3, and 7) were new. A new benzofuran derivative (8) of the farnesyl hydroquinone ganomycin B was also identified. The structures and relative configurations of the new compounds were elucidated by comprehensive spectroscopic analysis and by comparison of their NMR data with those of related compounds. The lanostanes exhibited in vitro antiplasmodial activity with IC(50) values from 6 to greater than 20 microM.

PMID: 20384295 [PubMed - indexed for MEDLINE]