靈芝裡蘊藏的三萜類之豐富，科學家挖掘了近四十年還挖掘不完，目前已經知道的就快二百種，作用巧妙也不盡相同。

韓國大邱加圖立大學發表的研究報告則指出，從靈芝子實體的乙酸乙酯萃取物，分離出數種固醇類和三萜類物質，包括麥角固醇、靈芝酸Ｓz、羊毛固二烯型三萜類（lanostadiene type triterpene）等，其對補體活性的抑制作用，可緩解自體免疫引起的溶血性貧血（補體攻擊紅血球造成的貧血）。

（以上文章原刊登於49期《健康靈芝》雜誌）4495

Steroids and triterpenes from the fruit bodies of Ganoderma lucidum and their anti-complement activity.
Seo HW, Hung TM, Na M, Jung HJ, Kim JC, Choi JS, Kim JH, Lee HK, Lee I, Bae K, Hattori M, Min BS.
Source
College of Pharmacy, Catholic University of Daegu, Gyeongsan, Gyeongbuk 712-702, Korea.

Abstract
To determine the anti-complement activity of natural triterpenes, chromatographic separation of the EtOAc-soluble fraction from the fruiting body of Ganoderma lucidum led to the isolation of three steroids and five triterpenoids. They were identified as ergosterol peroxide (1), ergosterol (2), genoderic acid Sz (3), stella sterol (4), ganoderic aic C1 (5), ganoderic acid A (6), methyl ganoderate A (7), and lucidenic acid A (8) based on spectroscopic evidence and physicochemical properties. These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Compounds 2 and 3 showed potent anti-complement activity with IC50 values of 52.0 and 44.6 microM, respectively. Compound 1 exhibited significant inhibitory activity with an IC50 value of 126.8 microM, whereas compounds 4-8 were inactive. Our findings suggested that in addition to the ketone group at C-3, the delta7(8), delta9(11)-lanostadiene type triterpene also plays an important role in inhibiting the hemolytic activity of human serum against erythrocytes.

PMID: 20091270 [PubMed - indexed for MEDLINE]

［資料來源］Seo HW, et al.: Steroids and triterpenes from the fruit bodies of Ganoderma lucidum and their anti-complement activity. Arch Pharm Res. 2009 Nov;32(11):1573-9.

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